North America’s largest casino and hotel resort is owned and operated by the Mashantucket Pequot Tribal Nation. Based in Connecticut, there are actually six casinos here, plus a bowling alley and multiple spas, as well as a whopping 38 restaurants — including three steakhouses, one of which is Craftsteak by noted restaurateur Tom Colicchio. Accommodations range from MGM Grand at Foxwoods, This casino hotel one of the Foxwoods spa offerings, to the secluded Two Trees Inn. At the Grand Pequot Tower, see if you can snag an exclusive villa with private butler service.

A lavish destination that maintains a boutique-ish atmosphere, the Palazzo is connected by the Grand Canal Shoppes arcade to its Las Vegas sister property The Venetian. The Palazzo’s European-inspired casino hotels features all the usual trappings as well as an immense, 112,000-square-foot poker room with hand-painted frescoed ceilings.The Palazzo’s rooms are all suites — with sunken living rooms and marble-covered bathrooms. If there’s any spare time you’re not rigorously devoting to relaxing and rejuvenating in your suite, check into the multi-level Canyon Ranch SpaClub, also shared with the Venetian.

Inside an elegantly restored, 19th century Spanish colonial façade is the two-story Regency Casino hotel Mendoza. European-style ambiance and personal service is enjoyed by gamblers from all over the world who come to try their luck at punto y banca, a variation of baccarat.Whether you’re looking to enjoy fine wine or just drink away a losing streak at the blackjack tables, enjoy and take solace in the fact that the Park Hyatt Mendoza is surrounded by major wineries along the Andes mountain range — which also provides up some of the best ski resorts.